| Dan Castellaneta | Homer Simpson / Abe Simpson / Barney Gumble / Krusty (voice) |
| Julie Kavner | Marge Simpson / Patty Bouvier / Selma Bouvier (voice) |
| Nancy Cartwright | Bart Simpson / Nelson Muntz / Ralph Wiggum (voice) |
| Yeardley Smith | Lisa Simpson (voice) |
| Hank Azaria | Moe Szyslak / Chief Wiggum / Apu / Comic Book Guy / Carl (voice) |
| Harry Shearer | Ned Flanders / Mr. Burns / Smithers / Skinner / Lenny (voice) |
| Billy West | Philip J. Fry / Dr. Zoidberg / Professor Farnsworth (voice) |
| David Herman | Scruffy (voice) |
| Frank Welker | Santa's Little Helper / various animals (voice) |
| John DiMaggio | Bender (voice) |
| Katey Sagal | Leela (voice) |
| Lauren Tom | Amy Wong (voice) |
| Phil LaMarr | Hermes Conrad / Auctioneer / Male party guest (voice) |
| Maurice LaMarche | Army recruiter 2 / Billy / others characters (voice) |